I would say the Life Cafe, but unfortunately it closed. It was a great destination for those who love the show RENT.
Other than that there's Tonic in Times Square as well as Haru (sushi). Life Cafe was incredible, best burger I've had ever, but again it closed recently. I think the lease on the building went up. There is still one in Brooklyn, but the original one where Jonathan Larson wrote RENT is closed.
Other good food places are any street vendor, though none of it is healthy and then a place called Famiglia Pizza. It's near the Capezio store in Times Square. Best pizza ever.