I think everyone is different in how they break in their skates, as well as how long it takes. My last pair, I would say in just about a week of skating (so maybe 4-5 hours on the ice) I was 100% comfortable skating in them, I had no problem with ankle bend (I was doing sit spins on day one) and the only thing stopping me from trying more initially was the temporary mount on the blades. It took another week or so after that before I no longer noticed that "new skate" feeling when lacing them up. The pair before that, I remember it felt a month or more before they really felt "right" but I was also returning to the ice after a lengthy time off so I wasn't skating as strongly or as often as I do now.
My coach recommends lots of backwards crossovers to start the process of getting the ankles to bend, and then as you get more comfortable, moving on to moves in the field (lots of turns, edges, power pulls, etc), followed by spinning and then jumping (edge jumps mostly, very limited toe jumps). Glide tests forwards and backwards are useful for determining final blade position if the need for adjustments hasn't already been identified by everything else.